Article in Nature Medicine reports data from study at the University of Texas Medical Branch at Galveston (UTMB) showing protection against Lassa Fever, a major threat to global health
Zalgen Labs LLC (Zalgen), a biotechnology and diagnostics company focused on high-impact, neglected infectious diseases including Lassa Fever (LF), today announced that Arevirumab-3, its lead immunotherapeutic candidate, was tested against NHP infected with Lassa and demonstrated 100% protection. The study emanated from an extensive research collaboration of the Viral Hemorrhagic Fever Consortium (VHFC) and the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC) working on advanced alternatives to treat Lassa fever infections.
Researchers at UTMB successfully tested Arevirumab-3, a cocktail of human monoclonal antibodies developed by Zalgen and Tulane University (Tulane). This first-in-class seminal study was published in the September 4, 2017 issue of the journal Nature Medicine (Mire, et al.) Arevirumab-3 has now demonstrated 100 percent efficacy in two relevant model systems, and will advance to pre-clinical development, with projected Phase I studied within three years.
Lassa fever is a dangerous, often fatal disease common to much of West Africa with children and pregnant women being the highest risk groups; early stages of the disease are difficult to distinguish from other diseases. Lassa fever is spread by contact with infected rodents and is estimated to infect 300,000 to 500,000 people per year across the region, with at least 5,000 deaths reported annually. The illness is characterized by bleeding and coagulation abnormalities, with mortality rates reported exceeding 25 percent and reaching 50 percent during epidemics.
“The fact that Arevirumab-3 was able to rescue 100% of monkeys more than a week after infection with Lassa virus suggests that this therapy may benefit patients with Lassa fever in West Africa, who often present to the clinic at a late stage of disease,” said Luis M Branco, Ph.D., Managing Director and Co-Founder of Zalgen Labs. “We are accelerating further development of Arevirumab-3 so that this promising treatment can be introduced into clinics in West Africa and deployed as a deterrent against the use of Lassa virus as a bioweapon.”
Development of Aruvirumab-3 was supported by the National Institutes of Health (NIH) grants BAA NIAID-DAIT-NIHAI2008031, 1 R01 AI104621-01, 1 U19 AI109762-01, 1R01AI132223-01, 1 R43 AI120472-01, and peripherally by 5 R44 AI115752-02, 1 U01 AI082119-01, and 1 UC1 AI067188-01.
About Zalgen Labs
Zalgen Labs is a biotechnology and diagnostics company with headquarters in Germantown, Md., and an advanced diagnostic product development center in Aurora, Colo. The company specializes in the design and production of superior biological molecules critical for the development and commercialization of immunotherapeutics, novel vaccines, and reliable, rapid and affordable diagnostic platforms targeting neglected and underrepresented human infectious diseases. For more information, visit www.zalgenlabs.com.
About the Viral Hemorrhagic Fever Immunotherapeutic Consortium
The Viral Hemorrhagic Fever Immunotherapeutic Consortium was established in 2014 to develop life-saving antibody therapeutics against some of the world’s deadliest viruses. The VIC represents a field-wide collaboration in which leading laboratories around the world have united to understand what features lead to antibody-mediated protection against these viruses and how we can more rapidly discover ideal treatments. This collaborative effort allows each laboratory to contribute their strengths in analytical techniques towards the identification, characterization, and validation of antibodies against the filoviridae and arenaviridae families. From isolating novel antibodies and testing them in vivo, to the structural analysis of the molecular mechanisms of neutralization, VIC scientists contribute unique insights towards the overall characterization of a broad pool of antibodies. The consortium is funded through a National Institute of Health National Institute of Allergy and Infectious Diseases Centers for Excellence in Translational Research program grant. For more information, visit www.vic.org.
About the Viral Hemorrhagic Fever Consortium
The Viral Hemorrhagic Fever Consortium was established in 2010 as a result of several multi-year grants and contracts awarded to Tulane University by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to support Tulane’s ongoing efforts to treat and prevent Lassa fever. For more information, visit www.vhfc.org.
Zalgen Company Contact
Luis M. Branco, Ph.D. – Managing Director and Co-Founder
Phone (720) 859-3550